If you are only made up of matter/energy, why do you trust your senses as generally accurate (if you do)?
The answer would seem to be, "Because those are all we have." It is not possible to gain any experience without the senses. We therefore are constrained and this becomes our real reality.
It would not matter if, in truth, the universe were completely different from the way we perceive it -> we have been successful so far based upon how our senses tell us it is.