I'm not a physicist but it seems to me that E=mc2 demonstrates that, whilst a tiny amount of matter can be turned into an enormous amount of energy, the opposite is also true. It would take an enormous amount of energy to create a tiny amount of matter.
However, it also seems to me that, although the amount of matter in the known universe is tiny in comparison with the volume of the universe, it is too tiny. We have a good idea of the energy levels of the Big Bang but there is insufficient observable matter to tie into them. AIUI the question of what this unobserved matter is what the LHC is trying to detect by using energy to create matter in the form of sub-atomic particles. If these particles can be created and detected artificially then their theoretical existence, which would account for the "missing" matter in the universe will have been proven.
But I'm probably completely wrong.