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His death was caused by complications related to autoimmune inflammatory vasculitis, a condition Ramis battled for four years, according to United Talent Agency, which represented Ramis for many years.Ramis died Monday morning in his Chicago-area home, the agency said.For more than 40 years, Ramis was a leading figure in comedy. A veteran of the Second City troupe in his hometown of Chicago, he was a writer for "SCTV" and wrote or co-wrote the scripts for "National Lampoon's Animal House" (1978), "Caddyshack" (1980), "Stripes" (1981), "Ghostbusters" (1984), "Groundhog Day" (1993) and "Analyze This" (1999).The films often featured members of his generation of comedy talents -- veterans of the National Lampoon's recordings, "Saturday Night Live" and "Second City TV" -- most notably Ramis' old comedy colleague and fellow Chicagoan Bill Murray.His directing credits include "Caddyshack," "National Lampoon's Vacation" (1983), "Groundhog Day," "Analyze This" and -- in a change from his usual comedies -- the dark 2005 film "The Ice Harvest." He occasionally acted as well, most notably playing Murray's friend in "Stripes," Dr. Egon Spengler in "Ghostbusters" and a doctor in "As Good as It Gets" (1997)."Ghostbusters" star Dan Aykroyd wrote on Facebook, "Deeply saddened to hear of the passing of my brilliant, gifted, funny friend, co-writer/performer and teacher Harold Ramis. May he now get the answers he was always seeking."Steve Carell, who worked with Ramis on "The Office," tweeted, "Harold Ramis. Funny, gracious, kind hearted. A joy to have known you."Ramis directed several episodes of that TV series.Ramis' films were some of the most influential -- and highest-grossing -- comedies of recent decades. "Animal House" remains a model for knockabout laughs and gross-out moments. "Caddyshack" is eminently quotable. "Ghostbusters" was the second-biggest box office hit of 1984, just behind "Beverly Hills Cop."