There is a falsifiable way to prove there is no 'soul' necessary to drive a body.
As I have mentioned before, simulate a brain+body in a computer. Get a logically equivalent neural network running in realtime, and put real creatures, and then real people into a computer simulated world.
It would demonstrate that we are information, not magical woo.
That a copy of you could live forever, but through technology, not talking to imaginary friends.
And it would be super useful. Not just for the 'immortality'. For spreading humans and other life throughout the universe, where in 99.999999-% of it, machinery with basic energy/maintenance requirements is far more suitable than life support for fragile things evolved to live briefly in a gravity well, surrounded by all kinds of idiosyncratic nutritional and biological requirements.
Realistically, this would not 'disprove' the soul to anyone who wants to believe in them. They would either claim the machinery was full of 'souls', or that only the meat machine version has a 'soul' to experience with, and the virtual people, convincing as they may be, are soulless automata. Of course this is pure solipsism and ignores the applicability of such arguments to your fellow meat machines.
The concept of 'soul' retreats from learning, just as their deities, demons, etc. retreat for learning.
Though the common definition of 'soul' would certainly shift to the information (code+data) that makes a person what they are, rather than some mystical retard woo.
This would at least be a definition of 'soul' that any reasonable person could agree on, and agree that it 'exists'.